Patterns of protein-protein interactions in salt solutions and implications for protein crystallization
نویسندگان
چکیده
منابع مشابه
Protein-Protein Interactions in Salt Solutions
Protein-protein interactions drive many biophysical processes of proteins in solutions, such as aggregation, solubility, and phase transitions including crystallization, gelation, and amorphous precipitation. Many of these processes are of significant research interest because of their practical importance. In the biopharmaceutical industry, it is crucial to prevent therapeutic proteins from ag...
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Discovering Domains Mediating Protein Interactions
Background: Protein-protein interactions do not provide any direct information regarding the domains within the proteins that mediate the interactions. The majority of proteins are multi domain proteins and the interaction between them is often defined by the pairs of their domains. Most of the former studies focus only on interacting domain pairs. However they do not consider the in...
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– The effective Coulomb interaction between globular proteins is calculated as a function of monovalent salt concentration cs, by explicit Molecular Dynamics simulations of pairs of model proteins in the presence of microscopic co and counterions. For discrete charge patterns of monovalent sites on the surface, the resulting osmotic virial coefficient B2 is found to be a strikingly non-monotoni...
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ژورنال
عنوان ژورنال: Protein Science
سال: 2007
ISSN: 0961-8368,1469-896X
DOI: 10.1110/ps.072957907